Synthesis of Some New Piperazine-iV^iV'-bis-substituted Derivatives As Potential Biologically Active Agents

In a search for new bactericidal and fungicidal agents some new piperazine-TV, TV'-bis-substituted derivatives have been prepared and characterized by their elemental analysis, IR, *H N M R , and mass spectral d a t a . T h e ant ibacter ia l and antifungal activities of all p repared c o m p o u n d s have been determined using Gentamycin as s t a n d a r d antibiotic. Some c o m p o u n d s showed a high activity equivalent t o t h a t of t h e s t a n d a r d towards Escherichia coli, Serratia marcescens, Bacillus cereus, Staphylococcus aureus, and Candida albicans.